Dosage ; See below
Combinations ; Captopril/Hydrochlorthiazide - see below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Angiopril | Torrent Pharmaceuticals Ltd. | Medox Pharmaceuticals Ltd. | 25mg | 100 | Tablet | per tablet | KES 750 |
| Capoten | Bristol-Meyers Squibb | Phillips Pharmaceuticals Ltd. | 25mg | 56 | Tablet | per tablet | KES 1,230 |
| Capoten | Bristol-Meyers Squibb | Phillips Pharmaceuticals Ltd. | 50mg | 56 | Tablet | per tablet | KES 2,200 |
| Capril | Maple Pharmaceuticals Pvt. Ltd | Njimia Pharmaceuticals Ltd. | 25mg | 30 | Tablet | per tablet | KES 140 |
| Captocos | Cosmos Limited. | Cosmos Limited | 25mg | 30 | Tablet | per tablet | KES 120.00 |
| Captolab | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 25mg | 100 | Tablet | per tablet | KES 225.00 |
| Captopril | Lupin Laboratories | Wessex Pharmaceuticals Limited | 25mg | 100 | Tablet | per tablet | KES 600 |
| Captopril | Lupin Laboratories | Wessex Pharmaceuticals Limited | 25mg | 56 | Tablet | per tablet | KES 300 |
| Captopril | Lupin Laboratories | Wessex Pharmaceuticals Limited | 50mg | 56 | Tablet | per tablet | KES 400 |
| Cardopril | Beximco Pharma | Madawa Pharmaceuticals Ltd. | 25mg | 100 | Tablet | per tablet | KES 378 |
| Epsitron | Remedica Ltd. | Twokay Chemicals Ltd | 25mg | 100 | Tablet | per tablet | KES 400.00 |
| Ropril | Aegis Ltd | Europa Healthcare Ltd. | 25mg | 20 | Tablet | per tablet | KES 300.00 |
| Ropril | Aegis Ltd | Europa Healthcare Ltd. | 50mg | 20 | Tablet | per tablet | KES 420 |
| Captopril More info | |
|---|---|
| Mode Of Action | Inhibition of the conversion of angiotensin I to angiotensin II. |
| Drug Indication | Mild to moderate hypertension; heart failure; diabetic nephropathy in insulin dependent diabetics and after myocardial infarction. |
| Precautions | Severe CCF, impaired renal function, lactation, aortic stenosis, NSAIDs, monitor serum lithium levels, first dose may cause hypotension especially in dehydrated cases, low sodium serum levels, diuretic treated cases, monitor renal function, may potentiate hypoglyceamic effects of insulin or oral hypoglycaemic agents, haematological monitoring. Avoid potassium sparing diuretics or potassium supplements. |
| Contra-Indications | Pregnancy, history of angioneurotic oedema with previous ACE inhibitors, hypersensitivity, renal vascular disease, porphyria. |
| Side Effects | Persistent dry cough, voice changes, chest pain, taste disturbances, bronchospasm, blood dyscrasias, tachycardia, increased serum potassium levels, anaphylactic reactions, hepatic /renal impairment, hypotension, GI disturbances, muscle cramps, sleep disturbances, flushing, asthenia, impotence, CVS disorders. |
| Dosage | Hypertension: 12.5-50mg BD or 50mg OD. Children: 0.3mg/kg TID (interval of alteration of the dose is 2-4 weeks). Heart failure: 6.25mg or 12.5mg TID initially under medical supervision. Maintenance: 25mg BD or TID. Diabetic nephropathy: 75-100mg. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTI NG ON THE CARDIO-VASCULAR SYSTEM |
| Drug Sub-Category | Angiotensin-converting enzyme inhibitors |
Captopril/Hydrochlorthiazide Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Capozide | Bristol-Meyers Squibb | Phillips Pharmaceuticals Ltd. | 50mg/12.5 mg | 28 | Tablet | per tablet | KES 1,100 |
| Captocos-H | Cosmos Limited. | Cosmos Limited | 25mg/12.5mg | 30 | Tablet | per tablet | KES 120 |
| Captopril-Denk | E-Denk OHG | Omaera Pharmaceuticals Ltd | 25mg | 100 | Tablet | per tablet | KES 600 |
| Captopril-Denk | E-Denk OHG | Omaera Pharmaceuticals Ltd | 25mg | 1000 | Tablet | per tablet | KES 1,341.18 |
| Captopril+HCT More info | |
|---|---|
| Mode Of Action | Inhibition of the conversion of angiotensin I to angiotensin II and diuresis |
| Drug Indication | Mild to moderate hypertension |
| Precautions | Severe CCF, impaired renal function, lactation, aortic stenosis, NSAIDs, monitor serum lithium levels, first dose may cause hypotension especially in dehydrated cases, low sodium serum levels, diuretic treated cases, monitor renal function, may potentiate hypoglyceamic effects of insulin or oral hypoglycaemic agents, haematological monitoring. Avoid potassium sparing diuretics or potassium supplements. |
| Contra-Indications | Pregnancy, history of angioneurotic oedema with previous ACE inhibitors, hypersensitivity, renal vascular disease, porphyria. |
| Side Effects | Persistent dry cough, voice changes, chest pain, taste disturbances, bronchospasm, blood dyscrasias, tachycardia, increased serum potassium levels, anaphylactic reactions, hepatic /renal impairment, hypotension, GI disturbances, muscle cramps, sleep disturbances, flushing, asthenia, impotence, CVS disorders. |
| Dosage | Dosing depends on stablization to individual components |
| Special Information | ACE inhibitor / thiazide diuretic to be used in-patients stabilized on the individual components in the same proportions. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |